M€ in open calls for proposals for a total Budget of 32.413 M€.
Grants for collaborative R&D Projects involving more than 2 independent entities established in 2 or more EU Member or Associated States, for the development of innovative products, services or processes.
Topic / Target >NMP.2012.1.3-1 Systematic investigations of the mechanisms and effects of engineered nanomaterial interactions with living systems and/or the environment


The rapid expansion of nanomaterials production and use in several products creates a need for understanding the mechanisms of nanomaterial
interactions with living systems, and the environment, along their life cycle from manufacturing to recycling and to final disposal processes.

Projects should be hypothesis driven investigations focusing on mechanisms of impact and seeking to identify to which degree commonalities across species exist. They should also seek to identify the key physicochemical parameters and surface functionalities of nanomaterials that control environmental fate and biological effects, influence release and (environmental) mobility. To this end, the used materials should be thoroughly characterised, to establish a relationship between material features and observed biological effects.

The overall aim is to identify commonalities across particle classes/types, resulting in a framework for classification of nanomaterials according to their biological impacts and to establish a link between nanomaterialbiomolecule interactions, the final sub-cellular localisation and the specific interference with cellular or extracellular signalling pathways (pathogenic mechanism) observed.

Proposals should address some or all of the following issues:
- Understanding the biological processes influenced by nanomaterials in living organisms throughout the life cycle of the nanomaterials.
- Quantification of nanomaterial interactions with biomolecules (proteins, lipids, sugars, nucleic acids) before and after uptake and localisation, and correlation of nanomaterialassociated biomolecules with nanomaterial fate & behaviour in cells / organisms / animals.
- Investigation of the potential for indirect effects related to nanoparticle exposure – e.g. genotoxicity, reproductive toxicity, immunological and signalling responses (including bystander effects between different cell types). Suitable endpoints for the assessment of indirect exposure effects should be defined and appropriate in vitro and in vivo methods for testing these should be assessed and validated. These should be suitable for nanomaterial testing, relevant in terms of outputs, and robust in terms of reliability and reproducibility.
- Systems biology approaches (transcriptomics, proteomics, metabolomics) to understand and compare pathogenic mechanisms of different nanomaterials across several species of increasing complexity.

In order to ensure industrial relevance and impact of the research effort, the active participation of industrial partners and other relevant parties such as authorities represents an added value to the activities and this will be reflected in the evaluation, under the criteria Implementation and Impact


Start date: 20/07/2011
End date: 08/11/2011
Total budget
for this call: 110.000.000
Consortia must consist of, at least, three independent legal entities from three different Member States or Associated Countries
(CP - IP) FP7-NMP-2012-LARGE-6 Large scale integrating collaborative projects

Ensuring the safety of nanontecnology

Nanotechnology-based applications will substantially improve the performance of many products through the unique properties of engineered nanoparticles. The same properties, however, raise questions and generate concerns with regard to potential health and safety risks. To support the safe development of nanotechnologies, these risks must be managed through identification of the hazard, knowledge of the potential adverse effects, measurement and control of the exposure. Risk management should become an integral part of the culture of the organisations involved in the supply chain. The objective is to support methods, techniques and equipment for occupational exposure assessment and risk reduction and mitigation; and their demonstration. The environmental fate and end-of-life treatment of products and waste containing nanomaterials are also of prime importance.

A key factor of success is the capacity to detect and measure the presence, mass, number and surface area of engineered nanoparticles; and to distinguish these from naturally occurring ones. These activities, in combination with the projects that have been launched with EU, national and international funding addressing the knowledge gaps on adverse effects on health and environment, will provide a good basis for risk management in industry and research facilities. A second objective is to prepare an 'intelligent testing' strategy to be applied for future toxicity testing of engineered nanoparticles. The variety of forms, functionalisation, and toxicity end-points necessitate a consistent strategy, streamlined with similar efforts around the world.
Nanosciences and nanotechnologies

Nanosciences and nanotechnologies research, development and innovation are governed by an integrated, safe and responsible policy framework. This development strategy is being implemented through a wide range of activities whose purpose it is to ensure that development and deployment of nanotechnology are carried out in a way that takes people's expectations and concerns into account, especially as regards human and environmental safety, and delivers tangible benefits for the citizen and the society.

Sales forecasts for products incorporating nanotechnology range from $1 trillion to $3 trillion by 2015. Current sales figures are still some way away from these figures, but the growth trend is following the projections. Indeed, nanotechnology research results have started to migrate from the confines of the laboratory towards real applications in various industrial sectors.

Societal, governance and health-safety-environment related issues must seamlessly accompany the development of industrial applications. Research must be complemented by, and provide support to a careful review of the regulatory landscape, reflections on ethical issues and outreach.

This is reflected in the WP structure, highlighting four areas of emphasis for nanosciences and nanotechnologies: Maximising the contribution of nanotechnology on sustainable development; Nanotechnology for benefiting Environment, Energy and Health; Ensuring safety of nanotechnology; and Cross-cutting and enabling R&D.

During the second half of FP7, the implementation is characterised by a gradual shift from fundamental research towards more application-oriented research. Faster introduction of nano-based applications into markets contributes to innovation-led competitiveness for European industry as well as provides significant societal and economic benefits.

In this context, the significant public investment made in nanotechnology research must provide a return to society in terms of contributing towards solutions to major societal challenges. Nanotechnology has significant potential to improve sustainability and to become a source of innovation in many industrial sectors.

The aim is, therefore, to cover important European Technology Platform related priorities for sustainability, e.g. in chemistry, construction, textile, fibres and forest based industries, transport and agro-food related sectors, with nanotechnology as the key enabling technology.

Further, Energy, Environment and Healthcare are at the forefront of global challenges, and of concern to every citizen. Notwithstanding the significant economic potential of environmental, energy and health technologies, nanotechnology must stand in the forefront for providing solutions.

In the light of available scientific evidence and public concerns associated with the potential risks of nanotechnologies and their applications, scientific investigators are strongly encouraged to pay renewed attention to safety – the safety of workers, the public and the environment. This Work Programme stresses not only the necessity to consider safety aspects from the beginning and the desirability of inherently safe design, but also requires that projects include a full scientific and/or technical risk assessment as well as proposals for risk mitigation measures, where appropriate.

Although safety is an integral part of all application related research, there is also a need for a more concerted approach. In nanosafety research, the emphasis of the NMP Theme is shifting from toxicology studies of individual nanomaterials towards more holistic safety assessment and management that manages overall risks. Agreed methods, techniques, equipment for toxicity studies, occupational exposure assessment and for risk reduction and mitigation will be an important part of this work.

As material systems and device structures become nanosized and nanostructured, significant challenges exist related to design and growth of these structures in a precise and reproducible manner. The analysis of their three-dimensional structure, properties and functions with a high level of precision poses another challenge. Detailed knowledge of e.g. the chemical, electronic and magnetic properties of nanomaterials is a pre-requisite for being able to tailor their functions in a controlled way. In the face of these challenges, the development of a wider range of nano-enabled applications requires continued significant R&D support in crosscutting areas and technologies, such as instrumentation, characterisation, modelling and design.
Nano-sciences, Nano-technologies, Materials and New Production Technologies

The objective of this theme is to improve the competitiveness of European industry and generate knowledge to ensure its transformation from a resource-intensive to a knowledge-intensive industry, by generating step changes in knowledge and implementing decisive knowledge for new applications at the crossroads between different technologies and disciplines.

This will benefit both new, high-tech industries and higher-value, knowledge-based traditional industries, with a special focus to the appropriate dissemination of RTD results to SMEs.

These activities are primarily concerned with enabling technologies which impact all industrial sectors and many other Seventh Framework Programme themes.
Total 2012 €
Project Name 2012 €Description
Innovative Sensor for the fast Analysis of Nanoparticles in Selected Target Products(INSTANT)3.771.946

INSTANT will face the challenge of the detection, identification and quantification of engineered nanoparticles (ENPs) in complex matrices such as cosmetic products and engineered food and drinks.... INSTANT


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